Targeting Protein-Protein Interactions by Small Molecules

<p>Part 1 Current strategies for the discovery of small-molecule inhibitors of protein–protein interactions.-&nbsp;Overview of Protein-protein Interactions and Small Molecule Inhibitors under Clinical Development.-&nbsp;High throughput screening in the discovery of small molecule inhibitors of protein-protein interactions.-&nbsp;Hot Spot-Based Design of Small-Molecule Inhibitors for Protein–Protein Interactions.-&nbsp;Computational Methods Applicable to the Discovery of Small-Molecule Inhibitors of Protein-Protein Interactions.-&nbsp;Experimental Methods Used for Identifying Small-Molecule Inhibitors of Protein-protein Interaction.-&nbsp;Fragment-based Drug Discovery for Developing Inhibitors of Protein-protein Interactions.-&nbsp;Part 2 Case studies of small-molecule inhibitors of protein–protein interactions.-&nbsp;Small molecule inhibitors targeting new targets of protein-protein interactions.-&nbsp;The Development of New Spirooxindoles Targeting the p53-MDM2 Protein-Protein Interactions for Cancer Therapy.-&nbsp;Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein−Protein Interaction.-&nbsp;Discovery and development of Keap1-Nrf2 protein-protein interaction inhibitors.-&nbsp;BRDT Inhibitors for Male Contraceptive Drug Discovery: Current Status.-&nbsp;Targeting Protein-Protein Interactions in Small GTPases.</p><p></p><p></p><p></p>